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OCR: ia the The major metabolic pathway proceeds tabolites reduction of ring A, and the resulting n le as are conjugated and excreted into the uri sulphates and glucuronosides, gens has The peripheral interconversion of andr important physiological consequences. Androstenedione is a major precursor c r source of testosterone and, in the female, is a maj he, and in this steroid. It is also converted to oestro oestrogen older women, when ovarian secretion one from is less important, the production of oest y to the androstenedione contributes significant total production of oestrogen.